Quick Glance: Common Multiple Sclerosis Symptoms
Multiple sclerosis (MS) can affect different neurological functions, so symptoms vary considerably between individuals.
Common multiple sclerosis symptoms include:
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Reduced or blurred vision in one eye, sometimes with pain during eye movement
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Double vision
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Numbness or tingling in the face, body, arms or legs
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Weakness affecting an arm or leg
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Muscle stiffness or spasms
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Difficulty with balance or walking
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An electric-shock-like sensation down the back when bending the neck forward (Lhermitte’s sign)
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Fatigue
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Problems with concentration, memory or information processing
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Bladder urgency, frequency or difficulty controlling urination
Multiple Sclerosis Symptoms That Should Not Be Ignored
The table below explains symptoms of multiple sclerosis that should not be ignored:
| Symptom or Change | What It May Indicate |
| Reduced vision in one eye with pain during eye movement | May occur with optic neuritis and requires neurological assessment |
| New double vision | May occur when nerve pathways controlling eye movement are affected |
| Persistent weakness in an arm or leg | A focal neurological change that requires assessment |
| Persistent numbness or altered sensation | May occur when sensory pathways within the central nervous system are affected |
| Increasing difficulty walking or maintaining balance | May reflect neurological involvement affecting movement or coordination |
| Electric-shock-like sensation when bending the neck forwards | May represent Lhermitte’s sign, which can occur with spinal-cord involvement |
| New bladder problems with other neurological symptoms | May occur when nerve pathways involved in bladder control are affected |
These symptoms cannot diagnose MS by themselves. Other neurological conditions can cause similar changes, so persistent or unexplained symptoms require proper assessment.
Why Do Multiple Sclerosis Symptoms Occur?
Multiple sclerosis symptoms occur when the immune system attacks the protective covering around nerve fibres in the central nervous system called myelin. This disrupts the normal transmission of electrical signals through the brain, spinal cord and optic nerves.
The symptoms depend on where this damage occurs. Involvement of the optic nerve can cause blurred or reduced vision and pain with eye movement. Damage to sensory pathways may lead to numbness, tingling or unusual sensations, while motor pathway involvement can cause weakness, stiffness or muscle spasms.
MS can also affect pathways involved in balance, coordination, bladder control and cognitive function. This may lead to unsteady walking, urinary urgency, difficulty concentrating or slower information processing.
Multiple Sclerosis Symptoms That Require Immediate Medical Attention
Symptoms of multiple sclerosis generally progress gradually rather than appearing as a sudden neurological event. Sudden neurological symptoms therefore, require immediate medical assessment, particularly when they involve:
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Sudden weakness or numbness on one side of the body
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Sudden loss or marked reduction of vision
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Sudden difficulty speaking or understanding speech
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Sudden severe loss of balance or coordination
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Sudden facial weakness
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Rapidly developing weakness that makes standing or walking difficult
These symptoms may indicate a stroke or another acute neurological condition and require urgent medical assessment.
Symptoms of Multiple Sclerosis Based on Type
The main types of multiple sclerosis differ primarily in how neurological symptoms develop and change over time.
The table below summarises typical multiple sclerosis symptom patterns based on type:
| Type of Multiple Sclerosis | Typical Symptom Pattern |
| Relapsing-remitting MS (RRMS) | New or worsening neurological symptoms occur during distinct relapses and then partly or completely improve |
| Secondary-progressive MS (SPMS) | Symptoms and disability gradually become more persistent after an earlier relapsing-remitting course |
| Primary-progressive MS (PPMS) | Neurological symptoms gradually worsen from the beginning, usually without clear relapses and remissions |
Symptoms of Multiple Sclerosis-Specific Conditions
Certain recognised neurological manifestations can occur as part of MS and may produce more characteristic symptom patterns.
The table below summarises some important symptoms of multiple sclerosis-associated conditions:
| MS-Associated Condition | Common Symptoms or Features |
| Optic neuritis | Reduced or blurred vision, usually affecting one eye, often accompanied by pain when moving the eye |
| Lhermitte’s sign | A brief electric-shock-like or altered sensation travelling down the back and sometimes into the limbs when the neck bends forward |
| Spasticity | Muscle stiffness, involuntary spasms, pain and difficulty with movement or mobility |
Multiple Sclerosis Symptoms in Children
Multiple sclerosis is uncommon in children, but children and teenagers can develop many of the same neurological symptoms seen in adults. Problems with concentration, coordination or school activities may make the changes more noticeable in everyday life.
Possible multiple sclerosis symptoms that may be observed in children by parents are:
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Changes in vision
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Numbness or tingling
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Muscle weakness
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Poor balance or coordination
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Tremor
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Fatigue that interferes with normal activity
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Difficulty concentrating or thinking clearly
Nearly all children diagnosed with MS have a relapsing-remitting pattern, with episodes of worsening symptoms followed by periods of recovery.
However, none of these symptoms confirms MS in a child. Other childhood conditions can cause similar symptoms, so unexplained neurological changes should be assessed by a specialist.
Can You Have Multiple Sclerosis Without Symptoms?
A person with multiple sclerosis may have periods when no symptoms are noticeable, particularly between relapses in relapsing-remitting MS. Symptoms can improve substantially or even appear to resolve before another episode occurs.
Sometimes, an MRI may show changes that look like those seen in MS even when a person has no typical symptoms. This is known as radiologically isolated syndrome (RIS). Some people with RIS later develop MS symptoms, while others remain symptom-free.
When Can Multiple Sclerosis Symptoms Become Life-Threatening?
Multiple sclerosis does not usually cause a sudden, life-threatening attack. However, sudden or severe neurological changes in someone with MS may represent serious complications.
The table below highlights symptoms that require emergency assessment:
| Symptom | Why It Is Serious |
| Sudden one-sided weakness or numbness | May indicate a stroke or another acute neurological problem |
| Sudden difficulty speaking or understanding speech | Can be a warning sign of stroke and requires immediate assessment |
| Sudden loss or marked reduction of vision | May indicate an acute neurological or eye-related emergency |
| Sudden severe loss of balance or coordination | Can occur with stroke or another acute neurological condition |
| Rapidly worsening weakness with inability to walk | Requires urgent assessment rather than being assumed to be an expected MS relapse |
How are Multiple Sclerosis Symptoms Diagnosed?
Multiple sclerosis cannot be diagnosed from symptoms alone. A neurologist considers the pattern and timing of neurological symptoms, together with examination findings, MRI, and other investigations, while excluding alternative causes.
The following tests and assessments may be used to diagnose symptoms of multiple sclerosis:
| Diagnostic Test or Assessment | What It Helps Establish |
| Medical history and neurological examination | Identifies patterns involving vision, strength, sensation, reflexes, movement, balance and coordination |
| MRI of the brain and spinal cord | Detects lesions within areas of the central nervous system typically affected by MS |
| Lumbar puncture | Examines cerebrospinal fluid for findings that may support an MS diagnosis |
| Visual evoked potentials (VEP) | Measures how efficiently signals travel along visual pathways |
| Optical coherence tomography (OCT) | Measures retinal nerve fiber thinning after optic neuritis, supportively detecting subtle optic nerve damage |
| Blood tests | Help exclude other conditions capable of causing similar neurological symptoms |
The symptoms and findings can have different causes, so no single symptom, MRI finding or laboratory result can confirm MS. A diagnosis requires consideration of the overall neurological picture and specialist assessment.
Frequently Asked Questions (FAQs)
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Q1. What can be an early sign of multiple sclerosis?
Ans. Multiple sclerosis may first cause reduced vision in one eye, double vision, persistent numbness, weakness or new balance problems. The first symptom varies according to the nerve pathway affected. -
Q2. Can multiple sclerosis begin with an eye problem?
Ans. Yes. Multiple sclerosis can first present with optic neuritis, causing reduced or blurred vision in one eye and pain when the eye moves. -
Q3. What can an altered sensation from multiple sclerosis feel like?
Ans. Multiple sclerosis-related sensory changes may feel like numbness, pins and needles, tingling or other unusual sensations. The location depends on the nerve pathways involved.
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References
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https://my.clevelandclinic.org/health/diseases/17248-multiple-sclerosis
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https://www.ninds.nih.gov/health-information/disorders/multiple-sclerosis-ms
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https://www.nationalmssociety.org/understanding-ms/what-is-ms/ms-symptoms/spasticity
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