How is Diphtheria Diagnosed?

Doctors diagnose diphtheria by examining symptoms and testing samples from the throat or other affected areas. A throat swab may be collected and sent to a laboratory to check for Corynebacterium diphtheriae.

Doctors can check the sample with a bacterial culture to see if the bacteria that cause diphtheria are present. They might also use a PCR test to find the bacteria’s genetic material and help confirm the diagnosis. Crucially, the lab must also perform toxigenicity testing (such as an Elek test or specialised PCR) to confirm that the specific bacterial strain is actively producing the dangerous diphtheria toxin.

How is Diphtheria Treated Based on Severity?

The common treatment methods followed by doctors for treating diphtheria based on its severity are mentioned below:

Severity Treatment approach
Mild Diphtheria Antibiotics (such as erythromycin or penicillin for 14 days) are given to eradicate the bacteria and prevent further toxin production. Diphtheria antitoxin (DAT) is required in all suspected toxigenic cases (not just considered) and can be given intramuscularly or intravenously.
Moderate Diphtheria Antibiotic treatment is required along with prompt administration of DAT. DAT is preferably administered intravenously (IV) rather than intramuscularly to rapidly neutralise circulating toxins, depending on the clinical assessment.
Severe or extensive respiratory Diphtheria This requires urgent hospital management, airway protection, antibiotics and DAT. In severe cases, DAT is preferably administered intravenously as a single high-dose infusion to neutralise circulating toxin and limit disease progression.

Types of Diphtheria and Their Treatment

There are two main types of diphtheria, along with their specific treatment approaches:

Type of Diphtheria Treatment
Respiratory Diphtheria Respiratory diphtheria is treated with diphtheria antitoxin and antibiotics, along with close monitoring of the airway to manage any breathing difficulties.
Cutaneous Diphtheria Cutaneous diphtheria is treated with antibiotics along with appropriate care of the affected skin and wounds.

Oral Medications for Diphtheria Treatment

Some medications used to treat diphtheria are:

  • Erythromycin: It is a macrolide antibiotic used to treat diphtheria by helping eliminate the bacteria from the body. It may be prescribed for 14 days for people with diphtheria and can be recommended for those who have been in close contact with an infected person.

  • Diphtheria Antitoxin (DAT): Helps neutralise the diphtheria toxin that has not yet entered cells. It is administered intravenously or intramuscularly (never orally) and should be given as soon as diphtheria is suspected because early treatment is more effective.

  • Penicillin: Penicillin can be used to treat diphtheria and eliminate the bacteria from infected patients or carriers. It may also be considered when erythromycin is not tolerated or when adherence is a concern.

  • Aminoglycosides: Aminoglycosides may be added to the treatment regimen when diphtheria is complicated by endocarditis.

  • Azithromycin: Azithromycin is another macrolide antibiotic that may be used as an alternative when erythromycin is not suitable.

Note: Medicines should be taken only on the advice of a qualified doctor. Do not start, stop or change any medicine or dosage without medical guidance.

Other Treatments for Diphtheria

Here are some additional treatment options that may be used in managing diphtheria:

  • Airway Support: When a thick membrane and swelling in the throat make breathing hard, patients with respiratory diphtheria need to be watched closely. If their airway becomes blocked, advanced support may be needed. Acting quickly can help prevent serious problems.

  • Oxygen Therapy: If a patient has trouble breathing or low oxygen levels, they may need extra oxygen. In more serious cases, a ventilator might be needed. The amount of support depends on how the patient is doing.

  • Isolation: Anyone who might have diphtheria should be kept apart from others to stop the spread. Infection-control steps are important until two consecutive clearance cultures taken 24 hours apart prove they are no longer contagious. People who have been in close contact may also need to be checked and given preventive care.

  • Heart Monitoring: Diphtheria toxin can affect the heart and cause myocarditis or abnormal heart rhythms. ECG monitoring and cardiac evaluation may therefore be required during recovery. Regular monitoring can help detect heart-related complications early.

  • Neurological Monitoring: Nerve damage can occur after diphtheria. Patients may need monitoring for weakness, difficulty swallowing or other neurological changes. Any new or worsening neurological symptoms should be reported promptly.

  • Vaccination and Booster Doses: Getting vaccinated is a key way to protect yourself from diphtheria. Patients recovering from diphtheria must still receive the complete vaccine series because the disease does not confer natural immunity. To stay protected, you may also need booster shots every 10 years as recommended.

Ayurvedic and Alternative Treatments for Diphtheria

Various Ayurvedic remedies and alternative treatments to manage diphtheria treatment may include:

  • Rasayana Therapy: Rasayana therapy includes traditional rejuvenation methods like Chyawanprash, which are known to help support immunity and overall recovery.

  • Tulsi: Tulsi is valued in Ayurveda for its antimicrobial and immune-supporting qualities, and it is often used as a traditional remedy for respiratory and throat health.

  • Guduchi (Giloy): Guduchi, also called giloy, has long been used to support the immune system and as a restorative herb to aid general weakness during recovery.

  • Turmeric: Turmeric is valued for its anti-inflammatory and antibacterial effects, and it may be used as part of supportive care.

  • Gandusha and Kavala: Gandusha and kavala are traditional gargling practices that use preparations like triphala or yashtimadhu to help soothe the throat.

  • Steam Inhalation: Steam inhalation with herbs like eucalyptus and tulsi is a traditional way to ease congestion and support respiratory comfort.

  • Honey: Traditionally used to soothe throat irritation and may be included as a supportive dietary measure.

  • Dietary Support: Light, warm and easily digestible foods such as moong dal soup and rice porridge are recommended during recovery.

Note: Avoid using unverified herbal products as a substitute for antibiotic treatment.

Home Care for Managing Diphtheria

Here are some tips you can follow to slow diphtheria progression:

  • Complete the full antibiotic course.

  • Maintain strict bed rest and avoid physical exertion.

  • Eat soft foods or warm liquids if you experience throat pain or difficulty swallowing

  • Make sure to follow the isolation instructions you were given.

  • Stay away from close contact with others until your healthcare provider says it is safe.

  • Watch for any difficulty breathing or unusual weakness, and seek medical help if these symptoms appear.

  • Make sure the people you live with or have been in close contact with get medical advice and testing if needed.

  • Avoid sharing utensils or personal items with an infected person.

How Long Does Diphtheria Treatment Take?

The recovery time after diphtheria treatment can vary depending on the severity of the infection and the treatment required, such as:

Treatment Approximate Duration
Antibiotic Treatment Treatment usually takes about 2 to 3 weeks to take effect.
Diphtheria Antitoxin (DAT) It usually takes 4-6 weeks, depending on the severity.

Diphtheria Treatment Side Effects

Patients may notice the following side effects after diphtheria antitoxin:

  • Hard lumps, redness, tenderness or warmth at the injection site

  • Headache

  • Difficulty moving

  • Joint pain

  • Loss of strength

  • Muscle aching or cramping

  • Muscle stiffness

  • Nausea

  • Pain in the arms or legs

  • Swollen joints

  • Vomiting

  • Fever

  • General feeling of discomfort or illness

  • Unusual tiredness or weakness

  • Chills

  • Dizziness

Lifestyle Changes for Managing Diphtheria

Making a few important lifestyle changes can help you manage diphtheria symptoms effectively. Some of the lifestyle changes that can help manage diphtheria include:

  • Maintain strict bed rest and avoid physical exertion or exercise during illness.

  • Keep vaccinations up to date.

  • Be sure to follow the isolation instructions given to you after your diagnosis.

  • If you notice any unusual throat symptoms, contact your doctor as soon as possible.

  • If your doctor recommends it, make sure your close contacts get the right preventive treatment.

  • Try to get enough good-quality sleep each night.

  • Eat a healthy, balanced and nutritious diet.

  • Exercise regularly to support overall health.

  • Wash your hands regularly with soap and clean water.

Factors That Increase the Risk of Diphtheria

Here are some factors that can increase the risk of diphtheria complications:

  • Travelling to areas where diphtheria is endemic or outbreaks are occurring.

  • Having a weak immune system.

  • Living or working in overcrowded places.

  • Not receiving the diphtheria vaccine.

  • Living in an area with low herd immunity.

  • Age under 5 or over 40 years (higher risk of fatal complications).

  • Missing recommended diphtheria booster doses.

Diphtheria Treatment Cost

The cost of diphtheria treatment in India can vary depending on the severity of the infection and the type of medical care required. A general physician consultation may cost around ₹500 to ₹2,000, while blood tests can range from ₹500 to ₹3,000, and throat swab culture and laboratory tests may cost approximately ₹800 to ₹2,500. If required, a chest X-ray may add around ₹500 to ₹2,500 to the overall expense.

You might also need to pay for antibiotics and other medicines, which usually cost between ₹1,000 and ₹10,000. Oxygen therapy can cost anywhere from ₹5,000 to ₹50,000. Each follow-up visit is typically about ₹500 to ₹2,000.

If a patient needs more intensive care, a hospital stay usually costs between ₹20,000 and ₹1.5 lakh. If ICU admission is needed, the cost can be much higher, from ₹50,000 to ₹3 lakh or more. The total amount you pay will depend on the patient’s condition, the hospital, how long the treatment lasts, and the type of care required.

Does Health Insurance Cover Diphtheria Treatment in India?

Yes, health insurance in India will cover expenses related to diphtheria treatment, depending on the policy terms. Some plans may cover some eligible inpatient expenses, prescriptions issued by physicians and day care treatments. Diagnostic tests, consultations, and medicines are covered as well with OPD cover. However, the expenses and applicable limits may differ from one policy to another.

For mild to moderate conditions that need hospitalisation, a minimum ₹5 lakh -10 lakh health insurance coverage might be enough. Consider coverage between ₹10 lakh and ₹15 lakh if you want more financial security for long-term hospital stays or high medical expenses.

Note: Examine the insurance policy's coverage limitations, exclusions, and claim conditions before opting for a mediclaim policy.

Frequently Asked Questions (FAQs)

  • Q1. Do close contacts of a person with diphtheria need treatment?

    Ans: Yes, even if they feel well, those who have had close contact with someone who has diphtheria, may require testing and treatment. In certain cases, further testing is required to confirm that the germs have been eliminated.
  • Q2. What is the main treatment for diphtheria?

    Ans: The main treatment for diphtheria is an antitoxin to neutralise the toxin, along with antibiotics to remove the bacteria. If breathing or other organs are affected, extra supportive care may be needed.
  • Q3. Can diphtheria be cured?

    Ans: Yes. Diphtheria can be treated with appropriate antibiotics and diphtheria antitoxin. Early treatment is important because the toxin can cause serious complications like nerve or kidney damage.
  • Q4. When should I seek medical help for suspected diphtheria?

    Ans: Seek urgent medical attention for diphtheria for a persistent sore throat which is accompanied by fever, swollen neck glands, difficulty swallowing, breathing difficulty or a thick grey or white membrane in the throat.
  • Q5. Can diphtheria affect breathing?

    Ans: Yes, diphtheria can cause a thick membrane and swelling in the throat, which can make it hard to breathe. If the airway becomes badly blocked, urgent medical care is needed.
  • Q6. Can vaccination prevent diphtheria?

    Ans: Yes, vaccination gives strong protection against diphtheria. However, this protection can fade over time, so getting booster shots as recommended is important.
  • Q7. What happens if diphtheria is left untreated?

    Ans: If diphtheria is not treated, it can block the airway, cause heart inflammation, nerve damage, and other serious problems. In severe cases, it can be life-threatening.
  • Q8. Can diphtheria affect the heart?

    Ans: Yes. The toxin produced by the bacteria can damage the heart and cause myocarditis or abnormal heart rhythms. Patients with respiratory diphtheria may therefore require cardiac monitoring.
  • Q9. How can I protect my family if someone has diphtheria?

    Ans: Try to limit close contact with diphtheria patients and follow your healthcare team’s advice about testing, antibiotics, and vaccination. Other people in your home may also need to see a doctor.
  • Q10. Can diphtheria spread from person to person?

    Ans: Yes, diphtheria can spread through respiratory droplets and close contact with an infected person. Avoiding close contact can help reduce the risk of transmission.
  • Q11. How long does diphtheria treatment take?

    Ans: The duration of diphtheria treatment depends on the severity of the infection and the response to antibiotics. Follow-up testing may also be needed to confirm that the bacteria have been cleared.
  • Q12. Can someone get diphtheria more than once?

    Ans: Yes, getting diphtheria does not always mean you are protected for life. It is still important to get vaccinated and keep up with booster shots.
  • Q13. Does diphtheria require hospitalisation?

    Ans: People who might have diphtheria sometimes need to go to the hospital, especially if they have trouble breathing or other serious symptoms. Hospital care helps prevent complications.
  • Q14. Can diphtheria cause nerve problems?

    Ans: Yes, the toxin from diphtheria bacteria can harm the nerves. This can cause weakness or make it hard to swallow or move.
  • Q15. Can diphtheria cause skin infections?

    Ans: Yes, diphtheria bacteria can sometimes cause skin infections, which may lead to sores or ulcers. These should be checked and treated by a doctor.

https://www.health.qld.gov.au/cdcg/index/diphtheria https://www.ncbi.nlm.nih.gov/books/NBK560911/

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